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Antibodies

• Antibodies are proteins produced by the immune system that bind specifically to antigens. They are used as tools in research to detect and isolate proteins, often tagged with labels to track their binding in assays.

Epigenetic Mechanisms

• DNA Methylation involves the addition of a methyl group to DNA, usually at cytosine bases, which can repress gene transcription.
• Histone Modification refers to post-translational changes to histone proteins, influencing chromatin structure and gene expression.
  • Histone Methylation (Lysine/Arginine): Addition of methyl groups to lysine or arginine residues on histones, leading to activation or repression of gene transcription depending on the site and number of methyl groups.
  • Histone Acetylation/Deacetylation: Addition/removal of acetyl groups on lysine residues of histones, which generally increases/decreases gene expression by altering chromatin structure.
  • Histone Phosphorylation: Addition of phosphate groups to histones, often associated with chromatin remodeling during DNA damage repair and cell cycle regulation.
  • Ubiquitination & SUMOylation: Addition of ubiquitin or SUMO proteins to histones, affecting protein stability, localization, and interactions.

RNA Processing & Modification

• RNA Processing & Modification involves the various processes that mature RNA transcripts, including splicing, capping, and methylation, which can influence RNA stability, localization, and translation.

Chromatin & Transcription

• Chromatin Remodeling: The alteration of chromatin structure to allow or restrict access to DNA, influencing gene transcription.
• DNA Replication & Transcription: The process of copying DNA during cell division and transcribing DNA into RNA for protein synthesis.
• Cell Growth, Development, & Differentiation: Processes that involve gene regulation to control cell proliferation, development of tissues, and cell specialization.

Cellular Structure & Function

• Cell Cycle: The series of events that cells undergo as they grow and divide.
• DNA Damage & Repair: Mechanisms that detect and repair DNA lesions to maintain genomic stability.
• Apoptosis & Cell Death: Programmed cell death processes critical for development and maintaining homeostasis.
• Cellular Structure & Trafficking: Organization of cellular components and transport of molecules within cells.
• Signal Transduction: Pathways that relay signals from cell surface receptors to intracellular targets to trigger responses.
  • Cell Surface Receptor & Kinase: Proteins on the cell membrane that respond to external signals.
  • Intracellular Kinase & Adaptor Protein: Molecules that relay signals inside the cell.
  • Phosphatase: Enzymes that remove phosphate groups from proteins, often deactivating signaling pathways.
  • Secreted Growth Factor: Molecules that promote cell growth and division.

Metabolism

• Glucose, Lipid, Protein, & Nucleotide Metabolism: Biochemical pathways that manage energy production, storage, and the synthesis and breakdown of molecules necessary for cellular function.

Immunology & Inflammation

• Cell Marker & Receptor, Cytokine: Molecules involved in immune signaling and communication.
• Other Immunology Antibodies: Various antibodies targeting immune system components for research.
• Other Primary & Secondary Antibodies: Primary antibodies bind directly to the target antigen, while secondary antibodies bind to primary antibodies to aid detection.

Tag Antibodies & Antibody Panel Packs

• Histone Modification Panel & DNA Methylation Panel: Sets of antibodies or assays that target multiple epigenetic markers for comprehensive analysis.

Research Kits & Sample Preparation

• DNA, RNA, Histone, Nuclear, & Whole Cell Preparation: Kits for isolating and preparing these biomolecules for analysis.
• Chromatin Preparation: Isolation of chromatin for studying protein-DNA interactions.

Next Generation Sequencing & Epigenetic Analysis

• DNA Bisulfite Conversion & Methylation Quantification: Techniques for studying DNA methylation patterns.
• Methylated DNA Immunoprecipitation (meDIP): A method for enriching methylated DNA.
• DNMT & DNA Demethylase Assay: Assays for studying enzymes that add or remove methyl groups from DNA.
• RNA Methylation & Chromatin Accessibility: Studies on RNA modifications and the openness of chromatin to understand gene regulation.

Chromatin Immunoprecipitation (ChIP), ChIP-seq, CUT&RUN

• Techniques for studying protein-DNA interactions and identifying binding sites across the genome.

Protein Post-Translational Modifications

• Histone Methylation, Acetylation, Deacetylation, Phosphorylation, SUMOylation, Citrullination: Diverse modifications affecting chromatin dynamics and gene regulation.
• DNA Damage & Repair Mechanisms & Gene Editing: Techniques for studying DNA integrity and manipulation of genetic material.

Proteins & Enzymes

• Modified & Unmodified Histones, Methylated DNA Binding Proteins, ADP Ribose, Chromatin Binding/Transcription Factors: Proteins involved in regulating DNA structure, function, and repair.

Peptides, Instruments, & COVID-19 Assays

• Histone Modification Peptides: Synthetic peptides for studying post-translational modifications.
• Sonication Devices, Magnets & Sample Mixers: Instruments for sample processing.
• COVID-19 Kits, Antibodies, & Proteins: Tools for detecting and studying SARS-CoV-2.

This summary outlines the key scientific processes and tools used for understanding molecular mechanisms, cellular functions, and the immune response, enabling comprehensive research in genetics, cell biology, and disease pathology.

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